4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-
Imidazole ketone erastin
CAS: 1801530-11-9
Molecular Formula: C35H35ClN6O5
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- - Names and Identifiers
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- - Physico-chemical Properties
| Molecular Formula | C35H35ClN6O5 |
| Molar Mass | 655.14 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Boling Point | 886.5±75.0 °C(Predicted) |
| Solubility | DMSO : 125 mg/mL (190.80 mM) |
| pKa | 6.12±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vivo study | In diffuse large B- cell lymphoma xenograft models, IKE inhibits system xc-, causes glutathione depletion, lipid peroxidation, and induces biomarkers of Iron death. |
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.526 ml | 7.632 ml | 15.264 ml |
| 5 mM | 0.305 ml | 1.526 ml | 3.053 ml |
| 10 mM | 0.153 ml | 0.763 ml | 1.526 ml |
| 5 mM | 0.031 ml | 0.153 ml | 0.305 ml |
Last Update：2024-01-02 23:10:35
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- - Reference Information
| biological activity | Imidazole ketone erastin (PUN30119, IKE) is an effective, metabolically stable, selective system xc-inhibitors as well as ferroptosis inducers. |
| Target | Value |
Last Update：2024-04-09 02:00:14
![4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-](http://res.chembk.com/assets/str/2d/1/18/1801530-11-9.png)
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QQ: 495145328
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View History
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-
3,6-二(乙基氨基)-9-[2-(甲氧羰基)苯基]-2,7-二甲基-占吨翁钼钨磷酸盐
盐酸喹那普利相关物质
聚(2-乙基己基丙烯酸酯)
叔丁基 1-氧杂-4,8-二氮杂螺[5.5]十一烷-4-甲酸酯
NH2-PEG-Tert(叔丁酯)
α-Methyl-1-pyreneMethanol
阿达帕林杂质C USP标准品
4-甲氧基-3,5-二甲基吡啶1-氧化物(奥美拉唑杂质)
(4-Chloro-1-methyl-1h-pyrazol-5-yl)methanamine dihydrochloride
3,6-二(乙基氨基)-9-[2-(甲氧羰基)苯基]-2,7-二甲基-占吨翁钼钨磷酸盐
盐酸喹那普利相关物质
聚(2-乙基己基丙烯酸酯)
叔丁基 1-氧杂-4,8-二氮杂螺[5.5]十一烷-4-甲酸酯
NH2-PEG-Tert(叔丁酯)
α-Methyl-1-pyreneMethanol
阿达帕林杂质C USP标准品
4-甲氧基-3,5-二甲基吡啶1-氧化物(奥美拉唑杂质)
(4-Chloro-1-methyl-1h-pyrazol-5-yl)methanamine dihydrochloride